Purpose. To evaluate primary trabeculectomy with adjunctive mitomycin-C (MMC) in diabetic patients without retinopathy with\nprimary angle-closure glaucoma (PACG). Design. This is a retrospective case series comparison. Participants. This retrospective\ntrial compared outcomes of 88 eyes that underwent trabeculectomy in patients with diabetes mellitus (DM) without retinopathy\nand in 97 patients without DM. Methods. In this study, the intraocular pressure (IOP), visual acuity, visual field, and\npostoperative complications were compared between the two groups. Qualified surgical success is defined as an IOP between 6\nand 18mmHg with or without topical antiglaucoma medication. Results. After a follow-up of 5 years, the IOP decreased from\na mean basal IOP of 27 8 �± 7 3mmHg to 15 0 �± 5 6mmHg in the DM group and from 27 3 �± 6 0mmHg to 12 4 �± 5 3mmHg\nin the control group. The mean number of antiglaucoma medications was 3 4 �± 1 3 and 3 3 �± 1 2 preoperatively (P = 0 587)\nwhereas it was 1 7 �± 1 5 and 1 1 �± 1 4 at the 5-year follow-up (P = 0 049). The 5-year qualified surgical success rates were\n42.9% and 65.4% for both groups (P = 0 046; log-rank test). Encysted blebs were seen in 21 (23.9%) patients in the DM group\nand in 12 (12.4%) patients in the control group (P = 0 041). Conclusion. PACG patients with DM without retinopathy\nundergoing primary trabeculectomy with MMC may have a lower long-term surgical survival rate compared with patients\nwithout DM.
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